CXCL12 expression reduces in initial stages of tumor during our study on its staging correlation, including BLCA, STAD, LUAD, LIHC, COADREAD, CESC,HNSC, BRCA, OV and UCEC indicating that CXCL12 potentially offers substantial clinical utility for diagnosing these tumors at an early stage (Figure 5). This evidence concerns the gene CXCL12 and neoplasm.