The key role of CXCL12 and its receptor, CXCR4, is in regulating the accumulation of stromal and immune cells within the microenvironment (TME).This process leads to the formation of a specific immune microenvironment that significantly impacts tumor growth, invasion, metastasis, angiogenesis, and drug resistance (40). The gene discussed is CXCL12; the disease is neoplasm.