As the insulinotropic effect of GIP is diminished in patients with type 2 diabetes (T2D) (2), the therapeutic potential of the GIP axis has been relatively underexplored, whilst structurally optimised agonists of GLP-1 receptors (GLP1R) have been developed and introduced for the treatment of T2D and obesity. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.