In newly diagnosed patients with metabolic syndrome, TNF-α was significantly associated with fasting blood glucose (r = 0.179, P = 0.021), LDL-C (r = 0.199, P = 0.01), atherogenic index (r = 0.219, P = 0.004), TG (r = 0.351, P < 0.001), and HDL-C (r = -0.244, P = 0.001) (20). The gene discussed is TNF; the disease is metabolic syndrome.