Disrupting this differentiation process, gain-of-function mutations in EZH2 and loss-of-function aberrations in the SWI/SNF complex (including ARID1A, PBRM1, and SMARCC2 mutations) are recurrent abnormalities in DLBCL, resulting in an aberrant proliferative dependency on EZH2 activity.11 The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.