A significant negative association between hyperuricemia and cognitive impairment was observed in individuals aged <70 years (OR = 0.34, 95% CI = 0.16–0.66, p = 0.003), males (OR = 0.46, 95% CI = 0.24–0.86, p = 0.018), those with a BMI <25 (OR = 0.31, 95% CI = 0.13–0.66, p = 0.005), those without hypertension (OR = 0.49, 95% CI = 0.20–1.11, p = 0.094), those without diabetes (OR = 0.52, 95% CI = 0.31–0.85, p = 0.012), and those with albumin levels <40 g/L (OR = 0.32, 95% CI = 0.13–0.74, p = 0.011), suggesting that hyperuricemia may be protective in these specific populations (Figure 1B). The gene discussed is ALB; the disease is Cognitive impairment.