MAPT and Alzheimer disease: Early-life events, such as neonatal hypoxia-ischemia (H/I), have been shown to induce AD-associated Aβ deposits and tau protein dysfunction, which can be further exacerbated by the presence of inflammatory microglia and macrophages at injury sites (Pluta et al., 2020; Pluta et al., 2018; Ulamek-Koziol et al., 2017).