Significant differences between MCI with awareness vs MCI with anosognosia in clinical features were HADS-Depression (t=−3.2, df=98, p=0.001), and HADS-Anxiety (t=−2.6, df=98, p=0.009) scores, while differences in biomarkers were limited to GFAP (t=−2.2, df=90, p=0.033). The gene discussed is GFAP; the disease is major depressive disorder.