<h4>Background</h4>Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is strongly associated with rare missense variants in <i>RYR2</i>, the gene encoding the intracellular calcium release channel RyR2. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.