Initial investigations were reported as dengue IgM ELISA positive, scrub IgM ELISA negative; thrombocytopenia; lymphocytic leukocytosis with raised C-reactive protein; deranged liver enzymes with direct hyperbilirubinemia; and deranged renal function, hyponatremia, and hyperkalemia (Table 1). Other infectious causes of acute hepatitis were ruled out. Here, CD40LG is linked to Acute hepatitis.