DMD and Duchenne muscular dystrophy: Poly(methacrylate)s.Poly(methyl methacrylate). In 2009, Rimessi et al. explored the use of cationic poly(methyl methacrylate) (PMMA) core–shell nanoparticles for the delivery of a 2′-O-methyl-phosphorothioate (2′OMePS) antisense oligonucleotide, M23D, to restore dystrophin expression in a mouse model of Duchenne muscular dystrophy (DMD) [165].