Osteoarthritis is the most prevalent musculoskeletal disease treated with curcumin, with Atabaki M et al. found that curcumin can reduce Visual Analog Scale (VAS) scores, C-reactive protein (CRP), CD4 and CD8 T cells, Th17 cells, and B cell frequencies to alleviate osteoarthritis (Atabaki et al., 2020). The gene discussed is CD8A; the disease is osteoarthritis.