AKT1 and neurodegenerative disease: Curcuma aromatica volatile oil, an active component from the dried roots of Curcuma aromatica, significantly reduces the phosphorylation levels of Tau protein (Thr231, Ser404) in AD mouse models, while increasing the expression of P-PI3K/PI3K and P-AKT/AKT, as shown by Qi Yue et al. (Yue et al., 2017).Paeoniflorin, the main bioactive component of Paeonia and a monoterpene glycoside, has beneficial effects on neurodegenerative diseases (Chao-fang et al., 2023).