MAPT and neurodegenerative disease: Studies have shown that after transfecting GSK-3β into rat brains, increased GSK-3β expression and abnormal Tau phosphorylation were detected, with Tau hyperphosphorylation co-localizing with GSK-3β, suggesting that GSK-3β-induced Tau hyperphosphorylation is involved in the mechanism of neurodegenerative diseases (Wang et al., 2013).