GSK3B and Alzheimer disease: Yuanzhi Powder has been shown to decrease the expression of P-Tau (Ser199)/Tau5 and P-Tau (Thr231)/Tau5 in the hippocampus of AD rat models, while increasing the expression of P-AKT/AKT and P-GSK-3β/GSK-3β (Peijun et al., 2020).