JAK2 and Cognitive impairment: Long et al. reported that Suanzaoren decoction alleviated cognitive deficits in an AD mouse model, reduced Aβ plaque deposition and neuronal loss, downregulated the expression of p-JAK2-Tyr1007 and p-STAT3-Tyr705 proteins, and modulated the JAK2/STAT3 pathway (Long et al., 2021).