Forsythoside A, a phenylethanoid glycoside isolated from the dried fruit of Forsythia (Qu et al., 2012), was shown by Chunyue Wang and colleagues to improve cell viability in AD models, reduce apoptosis rates, and downregulate caspase-3, -8, and -9 levels (Wang H. C. et al., 2020).Aconitine, a key active component of Aconitum, has pharmacological effects such as cardiotonic, analgesic, antitumor, and immune-modulatory properties (Xiu et al., 2019). Here, CASP3 is linked to Alzheimer disease.