Research conducted by Ma Tao and colleagues found that administering a decoction of Rehmannia to APPsw/PS1ΔE9 AD mouse models, the latency to enter a dark room was prolonged, the number of errors decreased, and the expression levels of SOD, GSH-PX, P-AKT, and P-GSK-3β effectively increased (Tao et al., 2014). This evidence concerns the gene SOD1 and Alzheimer disease.