MAPT and Alzheimer disease: In APP/PS1 AD mouse models, Forsythoside A has been reported to enhance memory and cognitive abilities, reduces Aβ plaque deposition in the brain, and inhibits Tau protein phosphorylation (Wang C. et al., 2020).Osthole, a coumarin metabolites extracted from Cnidium monnieri, was found by Ni Yingnan and colleagues to reduce the expression of P-Tau (Ser202), effectively enhances PI3K, P-AKT/AKT, and P-GSK-3β/GSK-3β expression, and alleviate cognitive dysfunction in AD mouse models (Ying-nan et al., 2019).