Studies have demonstrated that the TCM formula Jinsiwei(GAPT) exhibited the ability to improve learning and memory abilities in APP/PS1 Alzheimer’s disease (AD) mouse models by reducing the expression of phosphorylated Tau (P-Tau) and increasing the expression of P-AKT and P-AKT/AKT (Li, 2017; Zhuo, 2022). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.