Schisandrin and nootkatone, active metabolites of Schisandra chinensis and Alpinia oxyphylla, respectively, have been shown to significantly increase the expression of P-PI3K/PI3K, P-AKT/AKT, and P-GSK-3β/GSK-3β in Aβ1-42-induced AD cell models. This evidence concerns the gene AKT1 and Alzheimer disease.