Additionally, the modified formula San Jia San is capable of alleviating neuroinflammation in AD cell models by downregulating PI3K, P-AKT, IL-1β, IL-6, and TNF-α, while upregulating anti-inflammatory cytokines IL-4 and IL-10 (Miao, 2018). The gene discussed is AKT1; the disease is Alzheimer disease.