In ischemic cardiomyopathy, the myocardial Z-line and M-line sarcomeres are relatively clear, whereas Plin5-null mice exhibit severe mitochondrial deformation, increased oedema, reduced matrix density, and blurred mitochondrial cristae, indicating significant mitochondrial injury (Zheng et al., 2017). The gene discussed is PLIN5; the disease is ischemic cardiomyopathy.