SIRT1 and metabolic syndrome: In contrast, the MetS/E + EX group, which includes the SIRT1 inhibitor EX527, showed an insignificant change in body weight, liver weight index, TC, liver cholesterol content, TG, liver TG content, LDL, and VLDL compared to the MetS group (p = 0.35, 0.97, 0.99, 0.92, 0.16, 0.21, 0.52, and 0.16 respectively).