The results showed that main signal pathways involved Pathways in cancer, PI3K Akt signaling pathway, Proteoglycans in cancer, Focal induction, Ras signaling pathway, Endocrine resistance, EGFR tyrosine kinase inhibitor resistance, Rap1 signaling pathway, MAPK signaling pathway, etc. It could be seen that the pharmacological effect of Rhodiola-cSVD was intimately related to the PI3K-Akt pathway. The gene discussed is EGFR; the disease is cancer.