In contrast to the results of Le Douce et al. (2020[4]), Chen et al. (2022[2]) claimed that both 12-month-old 3xTg-AD mice and 10-month-old human P301S tau transgenic mice (PS19) expressed significantly higher hippocampal Phgdh than littermate wild control, as well as no, early, and late AD subjects displayed sequential increase of hippocampal Phgdh expression. The gene discussed is PHGDH; the disease is Alzheimer disease.