CRP and inflammatory bowel disease: For the significant associations identified in the primary and secondary analyses, we found the associations of the healthy and unhealthy PDIs with incident IBD and IBD-related surgeries were partially mediated by CRP levels (proportion 3.9–11.6%) and INFLA-score (8.9–22.3%), although clearly other mechanism are at play to explain the inverse proportion, which needs further research (Figure S7).