In addition to MMP-14, other ECM regulators, such as Procollagen C-Endopeptidase Enhancer 2 (PCOLCE2), a predictive marker for epithelial-to-mesenchymal transition and metastasis in lung cancer [60], were also observed with elevated synthesis levels in the dECM-tumors (Figure S8B). The gene discussed is PCOLCE2; the disease is lung carcinoma.