Interestingly, we observed a reduction in LAMA1 (which is an important component of the basement membrane in healthy lungs[54,55]) at tumor cell loci (Figure 6H,I right), suggesting that the tumor cells within the dECM-tumors exert a synergistic influence to remodel their extracellular environment through combined ECM-digestive and synthetic activities. Here, LAMA1 is linked to neoplasm.