For instance, we previously reported that early after burn tissues release danger signals that induce acute activation of several signaling pathways including Mammalian Target of Rapamycin (mTOR) and NFκB (6, 8, 14, 15, 26, 41–43) which drive the execution of metabolic cellular programing and inflammatory functions causing further local and systemic damage, and SIRS (44). This evidence concerns the gene NFKB1 and systemic inflammatory response syndrome.