N-Ras palmitoylation by the DHHC family of palmitoyl acyl transferases (PATs) and depalmitoylation by ABHD17 serine hydrolases is a dynamic process that is essential for the growth of acute myeloid leukemias (AMLs) harboring oncogenic <i>NRAS</i> mutations<sup>3-6</sup>. Here, NRAS is linked to acute myeloid leukemia.