Gene targeting experiments in mouse and analysis of Rbfox1 copy number variations in human has shown that Rbfox1 is a critical player in neuronal excitability and, like TrkB, has been associated with multiple psychiatric disorders and complex pathologies of the central nervous system (CNS) including epilepsy, autism spectrum disorders, Alzheimer and Parkinson diseases (Gehman et al., 2011; Lal et al., 2013; Lee et al., 2016; Lin et al., 2016; O’Leary et al., 2022; Raghavan et al., 2020; Wen et al., 2015; Weyn-Vanhentenryck et al., 2014). The gene discussed is RBFOX1; the disease is epilepsy.