Additionally mice infected with WT parasites showed local and systemic spikes in IL-10, TNF-α, IL-18, IL-6, CCL2, CCL3, CCL4, CCL11, G-CSF, and CXCL10 just prior to succumbing to infection, consistent with prior observations (17) and indicative of an agonal overinduction of proinflammatory cytokine activity (55, 56). Here, CXCL10 is linked to infection.