At present, the clinical diagnosis of DKD is based on the level of urinary albumin, which is generally characterized by persistent albuminuria with a urinary albumin/creatinine ratio (UACR) exceeding 30 mg/g and accompanied by decreased renal function (Selby and Taal, 2020); the estimated glomerular filtration rate (eGFR) and renal biopsy are also usually considered during such diagnosis (Oshima et al., 2021). This evidence concerns the gene ALB and diabetic kidney disease.