In summary, some of the identified proteins, SPARC-related modular calcium-binding protein 1 (SMOC1), complexin-2 (CPLX2), spondin-1 (SPON1), neurofilament light polypeptide (NFL), or alpha-1-antichymotrypsin complex (SERPINA3), have been reported in earlier plasma proteomic studies or are known AD biomarkers (e.g., NFL). The gene discussed is SPON1; the disease is Alzheimer disease.