Similar to the sex-stratified models, the interaction models for MCF2, HDAC8, SLC10A3, and FTX were additionally adjusted for APOE-ε4 allele positivity and/or AD neuropathology, where relevant, to see whether the genes had effects on tau tangles and cognition independent of APOE-ε4 and neuropathology. The gene discussed is MAPT; the disease is Alzheimer disease.