We observed a significant APOE-ε4 x sex x FTX interaction on longitudinal cognition (p = 0.03, Fig. 2E, Supplementary Table 5), whereby the male-specific protective effect of FTX expression on cognitive decline was driven by APOE-ε4 carriers (β = 0.05, p = 0.01, Fig. 2E). Here, APOE is linked to Mental deterioration.