Thus, we performed the largest and most comprehensive study of sex-specific transcriptomic associations with AD endophenotypes (i.e., Aβ plaques, tau tangles, and longitudinal cognition) to date leveraging bulk RNA sequencing (RNAseq) data from over 750 sex-matched decedents (spanning 1490 samples from the dorsolateral prefrontal cortex, posterior cingulate, and caudate nucleus) enrolled in the Religious Orders Study/Memory and Aging Project (ROS/MAP).10–12. The gene discussed is MAPT; the disease is Alzheimer disease.