KEGG analyses of LAM-EV identified top enriched pathways for DEP, including regulation of actin cytoskeleton, pathways in cancer, oxidative phosphorylation, metabolic pathways, estrogen signaling pathway, and endocytosis that are known to be involved in cancer progression, thus, supporting a potential involvement of LAM-EV in LAM progression. The gene discussed is TSC1; the disease is lymphangioleiomyomatosis.