In the MOG-induced experimental autoimmune encephalomyelitis (EAE) model of MS, a single prophylactic injection of TPC-MOG35-55 prior to disease induction significantly attenuated disease severity, whereas TP-treated mice developed clinical symptoms (Figures 6A, B, Supplementary Figures S3A–C). The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.