The KEGG analysis revealed that up-regulated genes were significantly enriched in Cytoskeleton in muscle cells, Focal Adhesion, ECM-receptor interaction, Focal adhesion, etc (Figure 3D), and down-regulated genes were mainly enriched in T cell receptor signaling pathway, natural killer cell mediated cytotoxicity, PD-L1 expression and PD-1 checkpoint pathway in cancer, etc (Figure 3E). Here, CD274 is linked to cancer.