PIK3CA and cancer: Alterations related to CKS1B mainly induce the changes of EGFR (18.8%), KRAS (20.5%), FGFR1 (8.5%), and BRAF (6.0%) genes for regulation of RTK-Ras signaling pathway (Figure 9A) as well as PTEN (6.4%), PIK3CA (18.0%), STK11 (10.8%), and RICTOR (9.8%) in the regulation of P13K/AKT signaling pathway (Figure 9B); TP53 (48.9%), and CDKN2A (22.4%) in TP53 signaling pathway (Figure 9C) for cancer proliferation and development.