Serum tumor marker findings, such as carcinoembryonic antigen(CEA), squamous cell carcinoma, carbohydrate antigen 72-4(CA72-4),19-9(CA19-9), 50(CA50), 242(CA242), 211, alpha-fetoprotein(AFP), and neuron-specific enolase(NSE) were all negative. The gene discussed is ENO2; the disease is squamous cell carcinoma.