Molecular features of cancer cells, such as activation of oncogenes, inactivation of tumor suppressor genes and epigenetic modifications, promote the activation of various transcription factors in the TME, such as NF-κB, STAT3, and HIF-1α, which induce the production soluble molecules by the cancer cells, creating an inflammatory TME (8, 9, 11, 35). Here, HIF1A is linked to cancer.