Forkhead box L1 (FOXL1), a member of the FOX superfamily (69, 70), is involved in cancer invasion and metastasis and shows abnormal expression in various tumors such as glioma (71), gallbladder cancer (70), pancreatic cancer (69), gastric cancer (72), and renal cancer (73). This evidence concerns the gene FOXL1 and gallbladder cancer.