In a study by Wang et al, it was found that the increase in lactate in obese mice mainly originated from white adipocytes, and the underlying mechanism was related to the increased expression of LDHA in adipocytes (16) In a seminal hypothesis proposed by Otto Warburg in 1956, it was posited that tumor cells, even in the presence of oxygen, favor glycolysis over oxidative phosphorylation (OXPHOS) for energy generation. Here, LDHA is linked to neoplasm.