MDM2 and neoplasm: For this patient, with elevating levels of human chorionic gonadotropin and α-fetoprotein, and other further screenings were all negative, which helps rule out malignancy, the final definitive diagnosis relied on histopathological analysis, that immunohistochemical staining showed that the tumor cells were negative for MDM2 and FISH analysis detected PLAG1 breakage and rearrangement.