Because we found possible association between HLA-DRB1⁣∗15.01 and HLA-DRB1⁣∗1.07 alleles with susceptibility to APS, we decided to analyze the potential association between all these HLA-DRB1 alleles and disease activity variables as well as aPL presence (Tables 7 and 8). This evidence concerns the gene HLA-DRB1 and autoimmune polyendocrinopathy.