Pooled analysis showed that the risk of hemorrhagic stroke (OR, 0.82(95 %CI: 0.42–1.60), P = 0.57), I2 = 0), ischemic stroke (OR, 0.85(95 %CI: 0.64–1.13), P = 0.26), I2 = 0), and embolic stroke (OR, 2.33(95 %CI: 0.49–11.09), P = 0.29), I2 = 0) was comparable between GLP-1 RA and placebo. This evidence concerns the gene GLP1R and ischemic stroke.