In summary, we found that presence or magnitude of a CD8 IFN-γ response was not associated with chlamydia reinfection status, but CD8 IFN-γ was associated with lower bacterial load among reinfected women and that most C. trachomatis-specific IFN-γ-producing CD8 T cells constituted effector memory cells, mostly Temra. Here, CD8A is linked to chlamydia trachomatis infectious disease.