Given that effector memory T cells can home to peripheral tissue sites of infection and aid in pathogen clearance, our finding that CD8 effector memory subsets dominated the C. trachomatis-specific IFN-γ responses when compared to CD4 T cells in which Tcm predominated, further supports the capacity of CD8 T cells to impact chlamydia clearance. The gene discussed is CD8A; the disease is infection.