KL and endothelial dysfunction: Klotho has a broad impact on biological function, as Klotho supplementation or overexpression has been demonstrated to protect against hypertension (Wang & Sun, 2009), endothelial dysfunction (Saito et al., 2000), atherosclerosis, (Yang et al., 2017) and vascular calcification (Hu et al., 2011; Hum et al., 2017).