SIRT7 and posterior cortical atrophy: The dual role of SIRT7 in cancer, acting as both a tumor suppressor and promoter, is primarily determined by its expression levels in tumors, regulation of specific oncogenes and tumor suppressor genes (TSGs), and the tumor microenvironment (TME) [109, 110] However, there is some controversy regarding the expression and function of SIRT7 in PCa.