PI3K (47.1% vs. 35.2%, p = 9.39e‐3) and TP53 (89.1% vs. 81.7%, p = 0.04) pathway alterations were more prevalent in early‐onset CRC among Hispanic/Latino patients, with AKT1 (5.1% vs. 1.8%, p = 0.03), INPP4B (4.3% vs. 1.4%, p = 0.04), and TSC1 (7.2% vs. 3.1% p = 0.03) gene alterations also significantly higher in this group. Here, TP53 is linked to colorectal carcinoma.