The article revealed that neurons express a variety of TLRs and that IFN‐gamma activation and energy deprivation cause an increase in TLR2 and TLR4 levels in neurons. The results identify a signaling route for TLR2 and TLR4 in neurons that promotes apoptosis and may make neurons susceptible to ischemia death. The gene discussed is IFNG; the disease is ischemia.