Notably, in CD8 naive T cells, we found a panel of genes associated with disease progression, including SH3BGRL3, IL10RA, PTGER2, PIM1, SH3BP5, and GPRIN3 (Figure 5C); there increased gradually from control to stable IPF to progressive IPF. Here, SH3BP5 is linked to idiopathic pulmonary fibrosis.