Enrichment analysis of these upregulated genes was conducted, with results showing that peripheral blood from SSc patients was enriched in pathways related to T cell migration (e.g., DEFA1B/DEFA1/ECM1, Padj = 0.0166) and mononuclear cell migration (e.g., CTSG/DEFA1B/DEFA1/C3AR1/ECM1, Padj = 0.0077). The gene discussed is DEFA1; the disease is systemic sclerosis.