Additionally, the CD30 pathway (TNFSF8 and TNFRSF8), CD40 pathway (CD40LG, ITGA5, ITGAM, ITGB1, ITGB2), and FLT3 signaling pathway (FLT3LG and FLT3) played significant roles in immune regulation of T cells in ILD patients. This evidence concerns the gene TNFRSF8 and interstitial lung disease.