However, under specific conditions, IFN‐γ signalling can also drive tumour survival, metastasis, and resistance to immune checkpoint blockade (ICB) by mechanisms such as downregulation of major histocompatibility complex (MHC) molecules, increased expression of indoleamine 2,3‐dioxygenase (IDO), and upregulation of PD‐L1.2, 5, 6, 7. This evidence concerns the gene IFNG and neoplasm.