RARA and acute myeloid leukemia: UMAP of these PCs suggests that DE-EVE ORF expression patterns in AML were independent of common cytogenetic abnormalities and morphological features (referring to the French-American-British [FAB] classification), with the exception of FAB-M3 (acute promyelocytic leukemia; equal to the cytogenic class of PML::RARA), which is a well-known prognostic factor in AML [33, 34] (Supplemental Figure S2b-c).