Since its discovery in 2012, cGAS-STING has been implicated in age-related inflammation and neuroinflammation, as have IFN-I genes IFNα and IFNß [141], while upregulation of the IFN-I pathway has been associated with AD [141, 142], tauopathy [143], and future cognitive decline [144], H-151 is a small molecule inhibitor of STING [145] that has been shown to suppress the induction of multiple IFN-I stimulated genes [146]. This evidence concerns the gene CGAS and tauopathy.