Here 2 (14 %) of 14 NSHL patients/families, who remained unsolved by WES, were diagnosed by WGS with DFNB84A, due to compound heterozygous mutations in PTPRQ. Three of the 4 pathogenic mutations escaped detection by WES because they were not or only insufficiently covered. The gene discussed is PTPRQ; the disease is nodular sclerosis classical Hodgkin lymphoma.