AGT and glomerulosclerosis: Mice that were subjected to UNx + Ang II infusion showed renal lesions, including glomerulosclerosis (Fig. 3A), tubular dilatation and atrophy (Fig. 3A), podocyte injury as evidenced by reduced numbers of WT1-positive podocytes in glomerular cross section (Fig. 3B), macrophage infiltration (Fig. 3C), and fibrogenesis or interstitial fibrosis indicated by αSMA expression (Fig. 3D) or collagen depositions (picrosirius red stain) (Fig. 3E).