In a spontaneous lung adenocarcinoma generated by the expression of the EGFR L858R in type II pneumocytes under the control of doxycycline (Dox),[21] induction of EGFR activated agrin expression within the multifocal adenocarcinomas when compared with adjacent or non‐induced lung tissues (Figure 2G,H). This evidence concerns the gene AGRN and lung adenocarcinoma.