LATS1 and neoplasm: Because Merlin phosphorylation at Ser518 is known to inactivate its tumor suppressor function,[29] this was reduced upon agrin silencing resulting in its activation coherent with our previous studies (Figure S8A, Supporting Information).[13e] Consequently, agrin knockdown increased LATS1 (pS909) phosphorylation which was reduced by sAgrin treatment (Figure S8A, Supporting Information), further indicating that the activation of core‐Hippo kinase occurs in the absence of agrin.