Interestingly, knock down of EGFR significantly suppressed the proliferative potential of EGFR‐mutant cell lines induced by sAgrin on compliant and stiff matrices, which could not be rescued by sAgrin, thus indicating that Agrin‐tuned matrix rigidity converges on EGFR to regulate cancer cell proliferation (Figure 3E,F). This evidence concerns the gene AGRN and cancer.