Consistent with a loss of spheroid growth and protrusive structures (Figure S8H, Supporting Information), YAP/TAZ depletion impaired the activation of Focal Adhesion Kinase (FAK), which was not rescued by sAgrin (Figure 6I), thus suggesting that YAP/TAZ is necessary for the adherence and proliferation of lung cancer cells on stiff matrix. Here, PTK2 is linked to lung carcinoma.