AGRN and lung cancer: Furthermore, in LUAD patients with EGFR mutations, higher expression of agrin was linked to poor OS (Figure 1B), aligning with the recent findings that identified a role of agrin in NSCLC.[16d,e] Importantly, lung cancer cell lines with EGFR mutations or exhibiting constitutive activation of downstream signaling exemplified by higher Akt activation showed elevated agrin mRNA and protein levels that correlated with EGFR status (Figure 1C,D).