YAP/TAZ are well‐defined mechanosensors that respond to tissue stiffness and other mechanical signals.[13, 28] Because agrin relays such mechanical signals to YAP/TAZ via integrins in liver cancer cells,[13e] the proposition of agrin‐dependent matrix sensitization of EGFR via YAP/TAZ activation becomes pertinent. This evidence concerns the gene EGFR and liver cancer.