To this end, we cultured lung carcinoma cell lines on polydimethylsiloxane (PDMS) pillars with diameters of 2 μm (that present a smaller adherent area and 6 μ height) and 4 μm (larger adhering area and 2 μ height) coated with fibronectin mimicking the “low or high mechanosensitive junctions” respectively. This evidence concerns the gene FN1 and lung carcinoma.