Likewise, agrin activated EphrinB2 in the erythroid niche that involved integrin β1.[35] Advancing previous observations of EGFR activation within integrin‐focal adhesion clusters,[10] our study suggests that agrin integrates EGFR signals to integrin‐focal adhesions during both localized adherence and bulk rigidity experiencing interfaces of cancer cells with their ECM. This evidence concerns the gene EFNB2 and cancer.