YAP/TAZ forms the roots of mechanosignaling associated with tumorigenesis and organ development.[36] Despite the evidence that YAP/TAZ mediate lapatinib resistance in stiff tumor environments for HER2‐amplified cancers,[37] not much is known as to how these signals are conveyed via EGFR from the stiff ECM and their relevance to tumorigenesis. Here, ERBB2 is linked to cancer.