The TRANCE (Tumor Necrosis Factor-Related Activation-Induced Cytokine) and IL-2RB (Interleukin-2 Receptor Beta) immune-related molecules [44, 45] exhibit significant predictive value for R-TB, with levels of TRANCE and IL-2RB being higher in R-TB than S-TB. This evidence concerns the gene TNFSF11 and tuberculosis.