PPA2 and neoplasm: Given that CRC cells often encounter hypoxic conditions during the metastatic process, such as acute hypoxia that may occur when passing through the hypoxemic portal vein and during early colonization of the hypoxic liver microenvironment, which results in abnormal death in tumor cells in this process (Loo et al, 2015), we investigated the impact of PPA2 depletion on cell viability and apoptosis under hypoxia.